The symptoms: your site throws error 503, or just a blank page with opcache extension enabled.
In some rare cases, you can try to add the next parameter to opcache.ini:
opcache.optimization_level=0
The opcache optimizer is not working very well in some cases, and PHP just crashes when opcache tries to optimize it. With opcache.optimization_level set to 0, it will just cache the content, no optimizations will be made.